General Clinical Chemistry Analyzers and Accessories
Abcam YM-155, survivin inhibitor, 5MG
MW 443.3 Da, Purity >98%. Novel small molecule potent survivin suppressant. Inhibits survivin promoter activity (IC₅₀ = 0.54 nM) and down-regulates survivin in vitro and in vivo. Induces apoptosis in human tumor cell lines in vitro at 10 nM, with little effect on other IAP or Bcl-2 family members.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Sulfamethoxazole hydroxylamine
Chemical. CAS 114438-33-4. Formula C10H11N3O4S. MW 269.28. Synthetic Metabolite of sulfamethoxazole, a sulfonamide bacteriostatic antibiotic. Has been shown to be an important component in sulfonamide hypersensitivity reactions and has been implicated in sulfonamide-mediated immunomodulatory effects. Shown to induce lymphocyte toxicity and suppression of proliferation. Compound can be used as analytical reference material.
Anton Paar Litesizer DIA Series analyzes particle size and shape via direct imaging. Easily switch between liquid, air, or free-fall dispersion. Automated feed and rinsing simplify operation for fast, reliable measurements.
Specifications Litesizer DIA 700Measurement Principle: Dynamic Image AnalysisMeasurement Ranges (Liquid Flow): 0.5 μm to 2,500 μmMeasurement Ranges (Dry Jet): 0.5 μm to 5,000 μmMeasurement Ranges (Free Fall):0.5 μm to 16,000 μm (restrictions apply for particles >8,000 μm)Camera: 5 Mpix (2,448 pixels x 2,048 pixels) / 0.5 μm per pixelData Collection Rate 220 fps/camera at 5 MpixMagnification: 0.3x, 1x and 6xOptical Features: _Automatic switch between objectives_Automatic merge of size ranges_All magnifications are included in the standard configuration-_Data Transfer: 1x 10 Gigabit Ethernet, 1x USB-A 3.0Measurement Output_Number-, surface-, and volume-weighted results_Size descriptors (ISO 9276-compliant): Minimum and maximum Feret diameters, projected area equivalent diameter, length, geodesic length and thickness (e.g., for fibers), minimum and maximum axes of the Legendre ellipse_Shape descriptors (ISO 9276-compliant): aspect ratio, ellipse ratio, irregul
Abcam PF-04929113 (SN x -5422), 50MG
MW 521.5 Da, Purity >99%. Potent and selective Hsp90 inhibitor (IC₅₀ = 50 nM). A Her-2 degradation inducer (IC₅₀ = 37 nM).
The product is subject to the following: Abcam Restricted Use Statement
Abcam Vistusertib (AZD2014), 10MG
MW 462.5 Da, Purity >98%. Novel potent and selective mammalian rapamycin (mTOR) inhibitor (IC₅₀ = 2.8 nM). Highly selective against multiple PI3K isoforms. Also targets P-Akt (IC₅₀ = 80 nM) and pS6 (IC₅₀ = 200 nM). An oral inhibitor with potential anti-neoplastic activity.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Ticagrelor, P2Y12 receptor antagonist, 50MG
MW 522.6 Da, Purity >98%. Reversible antagonist of the platelet purinergic P2Y12 receptor, the main receptor responsible for ADP-induced platelet aggregation. Changes the conformation of the P2Y12 receptor, resulting in reversible, concentration dependent inhibition of the receptor.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Z-Leu-Leu-Leu-CHO MG-132
Chemical. CAS 133407-82-6. Formula C26H41N3O5. MW 475.6. Potent, cell permeable and selective, reversible proteasome inhibitor. Blocks degradation of short-lived proteins and induces a heat shock response. NF-kappaB activation inhibitor through IkappaB degradation. Cell permeable, reversible peptide aldehyde inhibitor. Calpain and cathepsin inhibitor. Has anticancer properties by inducing cell cycle arrest and activating apoptosis in various cancer cell lines. Has adjuvant/chemosensitizer potential. Neurite outgrowth stimulator in PC12 cells. Prevents beta-secretase cleavage. Autophagy activator.
AdipoGen R-BAIBA
Chemical. CAS 2140-95-6. Formula C4H9NO2. MW 103.12. Synthetic Beta-Aminoisobutyric acid is a non-protein amino acid originating from the catabolism of thymine and valine. beta-Aminoisobutyric acid occurs in two isomeric forms and both enantiomers of beta-Aminoisobutyric acid can be detected in human urine and plasma. In plasma, the S-enantiomer is the predominant type due to active renal reabsorption. In contrast, urine almost exclusively contains the R-enantiomer of beta-Aminoisobutyric acid, which is eliminated both by filtration and tubular secretion. The S-enantiomer of beta-Aminoisobutyric acid is predominantly derived from the catabolism of valine, the R-enantiomer is the product of the catabolism of the pyrimidine bases uracil and thymine by the enzyme dihydropyrimidine dehydrogenase DPD, in what constitutes the first step of the pyrimidine degradation pathway.
Abcam GW-311616A, 1MG
MW 434 Da, Purity >=98%. A potent and selective intracellular neutrophil elastase (NE, alpha-1-proteinase) inhibitor. Inhibits human neutrophil elastase (HNE) and is selective over other human serine proteases with IC₅₀ values of 22 nM for HNE, >100 μM for trypsin, cathepsin G and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator.
The product is subject to the following: Abcam Restricted Use Statement
Abcam 4'-hydro x yazobenzene-2-carbo x ylic acid (HABA), 5G
MW 242.23 Da. An endogenous metabolite. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement